Gene description

Sequence information

Kaplan-Maier survival plot

EEG Scoring distribution

Representative mutant EEG

Zebrafish gene: kcna2b

Human gene: KCNA2 (potassium voltage-gated channel subfamily A member 2)

Homology score: 88%

ClinVar variants: 16

Gene description: Predicted to have delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to localize to axon; dendrite; and voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2).

ZFIN link: https://zfin.org/ZDB-GENE-080204-89​

Ensembl link: https://uswest.ensembl.org/Danio_rerio/Gene/Summary?db=core;g=ENSDARG00000102064;r=23:5009964-5032587;t=ENSDART00000163903​

Zebrafish reference(s): n/a

Sequences: 

This gene has 1 transcript (splice variant).

Guide RNA target sites: taatacgactcactataGGGGAGAGCTGCGGCTTCATgttttagagctagaa

Primers:

Forward primer: GCTGACAATTGAAAGGGAGTCC

Reverse primer: CGCCTGACTGGTAGTAATAGAG

Kaplan-Maier Survival Plot

EEG scoring distribution

N = 77

Representative mutant EEG